I wouldn't build around that, but it's there if you wanted to bring the heat
As everyone knows, Commander players start at 40 life, so Caduceus can start the game turned on
Im impressed by how much card advantage this commander generates despite not being blue
Cast a Sliver, cascade into another Sliver, cascade into another Sliver
Then, so long as you control four or more Humans, every Human you control gets +2/+2
One card you should especially play Queen of Hearts, Wonderland Empress with is Hades, King of Olympus because of its Sinister Plot ability - which gives Hades, King of Olympus the chance to quest for an extra lore for each villain in play - thereby synergising perfectly with Queen of Hearts, Wonderland Empress